BDBM50389154 CHEMBL2064666
SMILES COc1c(Nc2ncc(Cl)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)ccc2CC[C@@H](CCc12)N1CCOCC1
InChI Key InChIKey=LAJAFFLJAJMYLK-CVOKMOJFSA-N
Data 29 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50389154
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R & D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R & D
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of NPM-ALK phosphorylation in human SUP-M2 cells after 2 to 3 hrs by ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R & D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R & D
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human ALK expressed in baculovirus using recombinant GST PLC-gamma as substrate assessed as phosphorylation of the substrate after 15 m...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R & D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R & D
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of ALK tyrosine phosphorylation in human Karpas-299 cells after 2 hrs in presence of mouse plasmaMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R & D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R & D
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human ALK cytoplasmic domain expressed in baculovirus using GST-PLCgamma as substrate preincubated for 15 mins before substrate additio...More data for this Ligand-Target Pair